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  • Title: Rational Design of Mimic Multienzyme Systems in Hierarchically Porous Biomimetic Metal-Organic Frameworks.
    Author: Liu X, Qi W, Wang Y, Lin D, Yang X, Su R, He Z.
    Journal: ACS Appl Mater Interfaces; 2018 Oct 03; 10(39):33407-33415. PubMed ID: 30146872.
    Abstract:
    A facile approach was reported to establish mimic multienzyme systems with hierarchically porous (HP) biomimetic metal-organic frameworks (MOFs) and natural enzymes for tandem catalysis. The hierarchically porous MOF HP-PCN-224(Fe) with peroxidase-like activity and tunable hierarchical porosity was synthesized via a modulator-induced strategy. HP-PCN-224(Fe) not only acts as the enzyme-immobilization matrix but also as an effective enzyme mimic, which could cooperate with the immobilized natural enzyme to catalyze the cascade reactions. The mimic multienzyme systems were used for the efficient colorimetric detection of a series of biomolecules, including glucose and uric acid. This work displays the great potential to construct highly functional biocatalysts by integrating the merits of both natural enzymes and MOF mimics, which are promising for applications in biosensing and biomimetic catalysis.
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