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  • Title: Variant translocation t(7;922) during lymphoid blastic crisis in a case of Ph1-positive chronic myelogenous leukemia with previous EBV infection.
    Author: Mecucci C, Ghione F, Louwagie A, Criel A, Van den Berghe H.
    Journal: Acta Haematol; 1986; 75(1):46-8. PubMed ID: 3014795.
    Abstract:
    We report the case of a 19-year-old girl in whom a Ph1-positive chronic myeloid leukemia was diagnosed 10 months after an episode of infectious mononucleosis. Clinical and cytogenetical follow-up demonstrated the appearance of a variant Philadelphia chromosome translocation t(7;9;22) during a blastic crisis characterized by early B-lymphoid elements. The association between the t(7;9;22) variant Philadelphia and the lymphoid blast cells is emphasized, and the importance of Epstein-Barr virus (EBV) infection in the pathogenesis of the disease in this case is discussed.
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