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  • Title: [Characteristics of the interaction of restriction endonuclease BamHI with oligodeoxynucleotides].
    Author: Titeeva GR, Vinogradov SV, Berlin IuA.
    Journal: Bioorg Khim; 1986 May; 12(5):640-6. PubMed ID: 3015153.
    Abstract:
    Interaction of the restriction endonuclease BamHI with a series of synthetic oligodeoxynucleotides containing the restriction site has been studied. The enzyme is shown to specifically cut the BamHI site in hexanucleotide (I) and in non-selfcomplementary deca- and octanucleotides (II)-(IV). The data obtained led to the conclusion that BamHI reacts with duplex structures, while playing an important role in their stabilization. In 14-mer (V) BamHI cuts a non-standard half-site GAA to yield the 5'-terminal tri- (rather than hepta-) nucleotide. Hypothetical mechanisms of the process are discussed basing on conception of the role of higher DNA structures in the interaction with restriction endonucleases.
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