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  • Title: Cervical Cancer: Associations between Metabolic Parameters and Whole Lesion Histogram Analysis Derived from Simultaneous 18F-FDG-PET/MRI.
    Author: Meyer HJ, Purz S, Sabri O, Surov A.
    Journal: Contrast Media Mol Imaging; 2018; 2018():5063285. PubMed ID: 30154687.
    Abstract:
    Multimodal imaging has been increasingly used in oncology, especially in cervical cancer. By using a simultaneous positron emission (PET) and magnetic resonance imaging (MRI, PET/MRI) approach, PET and MRI can be obtained at the same time which minimizes motion artefacts and allows an exact imaging fusion, which is especially important in anatomically complex regions like the pelvis. The associations between functional parameters from MRI and 18F-FDG-PET reflecting different tumor aspects are complex with inconclusive results in cervical cancer. The present study correlates histogram analysis and 18F-FDG-PET parameters derived from simultaneous FDG-PET/MRI in cervical cancer. Overall, 18 female patients (age range: 32-79 years) with histopathologically confirmed squamous cell cervical carcinoma were retrospectively enrolled. All 18 patients underwent a whole-body simultaneous 18F-FDG-PET/MRI, including diffusion-weighted imaging (DWI) using b-values 0 and 1000 s/mm2. Apparent diffusion coefficient (ADC) histogram parameters included several percentiles, mean, min, max, mode, median, skewness, kurtosis, and entropy. Furthermore, mean and maximum standardized uptake values (SUVmean and SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were estimated. No statistically significant correlations were observed between SUVmax or SUVmean and ADC histogram parameters. TLG correlated inversely with p25 (r=-0.486, P=0.041), p75 (r=-0.490, P=0.039), p90 (r=-0.513, P=0.029), ADC median (r=-0.497, P=0.036), and ADC mode (r=-0.546, P=0.019). MTV also showed significant correlations with several ADC parameters: mean (r=-0.546, P=0.019), p10 (r=-0.473, P=0.047), p25 (r=-0.569, P=0.014), p75 (r=-0.576, P=0.012), p90 (r=-0.585, P=0.011), ADC median (r=-0.577, P=0.012), and ADC mode (r=-0.597, P=0.009). ADC histogram analysis and volume-based metabolic 18F-FDG-PET parameters are related to each other in cervical cancer.
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