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  • Title: Five New Diterpenoids from the Seeds of Euphorbia lathyris.
    Author: Wang Q, Zhen YQ, Gao F, Huang S, Zhou XL.
    Journal: Chem Biodivers; 2018 Nov; 15(11):e1800386. PubMed ID: 30156375.
    Abstract:
    A new premyrsinane-type diterpenoid, premylanin (1), and four new lathyrane-type diterpenoids named Euphorbia Factors L30 -L33 (2-5) were isolated from the seeds of Euphorbia lathyris, together with thirteen known ones (6-18). Their structures were elucidated through spectroscopic analyses, including IR, UV, HR-ESI-MS, 1D- and 2D-NMR. The cytotoxicities of compounds 1-4 and 6-18 against HCT116, MCF-7, 786-0, HepG2 cell lines were evaluated, and compound 13 exhibited considerable cytotoxic activities with an IC50 values of 6.44, 8.43, 15.3, 9.32 μm, respectively.
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