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  • Title: ATP-induced calcium mobilization and inositol 1,4,5-triphosphate formation in H-35 hepatoma cells.
    Author: Horstman DA, Tennes KA, Putney JW.
    Journal: FEBS Lett; 1986 Aug 18; 204(2):189-92. PubMed ID: 3015679.
    Abstract:
    Addition of ATP (but not epinephrine, angiotensin II, vasopressin, or platelet-activating factor) to H-35 hepatoma cells whose cellular lipids have been pre-labelled with [3H]inositol, causes a rapid increase in [3H]inositol triphosphate. In H-35 cells pre-incubated in the presence of 45Ca2+, ATP causes a similarly rapid release of 45Ca2+. The concentration-effect relationships for inositol triphosphate formation and Ca2+ efflux are similar to those reported previously for differentiated hepatocytes. These results demonstrate that at least one of the Ca2+-mobilizing receptors normally found on hepatocytes is functionally retained in the H-35 hepatoma cell line and thus could provide a useful model for the study of these receptor mechanisms in liver.
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