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  • Title: [Effect of guanosine-5'-monophosphate and inosine on the isolated heart of the frog].
    Author: Eliseev VV, Evdokimova NR, Luk'ianova IIu.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1986 Jun; 72(6):763-6. PubMed ID: 3015695.
    Abstract:
    The chronotropic and inotropic effects of guanosine-5'-monophosphate (5'-GMP) and inosine were investigated in isolated frog hearts. 5'-GMP induced biphasic chronotropic and inotropic responses: positive those were inhibited with propranolol, the negative inotropic response could not be inhibited with atropine. Inosine was able to enhance the positive inotropic response to 5'-GMP.
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