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  • Title: Cytotoxic antibiotic angucyclines and actinomycins from the Streptomyces sp. XZHG99T.
    Author: Bao J, He F, Li Y, Fang L, Wang K, Song J, Zhou J, Li Q, Zhang H.
    Journal: J Antibiot (Tokyo); 2018 Nov; 71(12):1018-1024. PubMed ID: 30158647.
    Abstract:
    Three new angucycline-type C-glycosides, grincamycins L-N (1-3), together with the known rabelomycin (4), moromycin B (5), fridamycin D (6), saquayamycin B1 (7), actinomycin X2 (8), and actinomycin D (9), were isolated from the culture of the soil-derived Streptomyces sp. XZHG99T collected from Color desert, Dengpa District, Tibet. The structures of 1-3 were established by detailed analyses of comprehensive spectroscopic data. Compounds 1-9 exhibited significant cytotoxicity against a panel of human cancer cell lines A549, H157, MCF7, MDA-MB-231, and HepG2, while 4, 8, and 9 showed decent antibacterial activity against Mycobacterium smegmatis and Staphylococcus aureus.
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