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  • Title: Presynaptic effects of cholecystokinin octapeptide on neuromuscular transmission in the frog.
    Author: Akasu T, Tsurusaki M, Ariyoshi M.
    Journal: Neurosci Lett; 1986 Jun 30; 67(3):329-33. PubMed ID: 3016613.
    Abstract:
    Intracellular recordings were obtained from the frog sartorius muscle end-plate to investigate the effects of cholecystokinin octapeptide (CCK-8) on cholinergic transmission at the neuromuscular junction. A brief bath-application of CCK-8 (1 microM) produced a depression, followed by a long-lasting facilitation, of the amplitude and the quantal content of the end-plate potential (epp). CCK-8 had a biphasic effect, an initial depression followed by an augmentation of the frequency of the miniature epps. CCK-8 did not affect the sensitivity of the nicotinic receptor at the end-plate. These results suggest a significant role for CCK-8 in cholinergic transmission, possibly as a modulator of the evoked release of acetylcholine from motor nerve terminals.
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