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  • Title: A highly selective fluorescent and chromogenic probe for CN- detection and its applications in bioimaging.
    Author: Wang Y, Wang J, Xian Q.
    Journal: Talanta; 2018 Dec 01; 190():487-491. PubMed ID: 30172538.
    Abstract:
    In this study, 3-ethyl-2-methylbenzothiazolium iodide and nitrophenyl-2-furancarboxaldehyde were used to synthesize a new fluorescent and chromogenic dual channel signal cyanide ion probe M, which showed high selectivity towards CN- analysis and strong antijamming capability towards other anions. When CN- is present in the solution, probe M indicates an obvious blue shift in UV-vis absorbance spectra, which can be observed clearly by unaided eyes. The limits of detection (LODs) of CN- based on fluorescence and UV-vis absorbance were 0.11 μM and 0.16 μM, respectively. The mechanism of fluorescent and chromogenic cyanide ion detection refers to the nucleophilic addition of cyanide ion to carbon atom of -C˭N- in the benzothiazole. The π-conjugation and ICT transition between furfural and benzothiazole were broken due to this non-reversible reaction, resulting in the color change and fluorescent characterizations. In addition, probe M also showed the excellent optical properties and high biocompatibility, which enables the practical application of CN- tracing in biomedical systems.
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