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  • Title: [Nanos2 in the male reproductive system: Progress in studies].
    Author: Huang ZY, Zhang XS.
    Journal: Zhonghua Nan Ke Xue; 2018 Jun; 24(6):558-561. PubMed ID: 30173464.
    Abstract:
    Nanos2, a member of the Nanos2 gene family, is a specific gene in male germ cells and encodes an evolutionarily conserved RNA binding protein expressed in male primordial germ cells (PGCs) during the embryonic period as well as in the spermatogonial stem cells (SSCs) of the testis. In the embryonic period, Nanos2 promotes the development of male PGCs and inhibits them from meiosis. In the process of spermatogenesis, Nanos2 suppresses the differentiation of SSCs in the testis and maintains the stability of the SSC pool. The knockout of Nanos2 may cause the disappearance of germ cells and sterility in male mice while its overexpression in the testis may lead to accumulation of SSCs in seminiferous tubules. Besides, Nanos2 is involved in the degradation of specific RNAs and possibly associated with some diseases of the male reproductive system. This review focuses on the recent progress in the studies of Nanos2 in the male reproductive system. Nanos2是Nanos基因家族成员之一，编码一种进化保守的RNA结合蛋白，其表达在胚胎期雄性原始生殖细胞（PGCs）和睾丸的精原干细胞（SSCs）内，是一种雄性生殖细胞特异性基因。胚胎发育期间，Nanos2能促进雄性PGCs发育并抑制其进入减数分裂；精子生成过程中，Nanos2可抑制睾丸SSCs分化进而维持SSC池稳定。敲除Nanos2基因能导致雄性小鼠生殖细胞的消失和不育，而睾丸Nanos2基因过表达则会引起生精小管内SSCs的累积。此外，Nanos2还参与特定RNAs的降解，并且可能与某些雄性生殖系统疾病相关。本文就近年来Nanos2在雄性生殖系统内的研究进展现予以综述。.
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