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Title: Diagnostic Performance of the Simultaneous Acquisition Rest ^{99 m}Tc-Tetrofosmin/Stress ²⁰¹Tl Dual-Isotope Protocol With a Semiconductor Camera　- Comparison With the Rest-Stress ^{99 m}Tc-Tetrofosmin Protocol.
Author: Kawamura I, Kajiura R, Motoji Y, Okamoto S, Tanigaki T, Omori H, Hirata T, Kikuchi J, Ota H, Sobue Y, Miyake T, Tsunekawa T, Kato T, Kawase Y, Okubo M, Kamiya H, Tsuchiya K, Tomita S, Hirakawa A, Kondo T, Suzuki T, Matsuo H.
Journal: Circ J; 2018 Oct 25; 82(11):2837-2844. PubMed ID: 30175800.
Abstract:
BACKGROUND: This study compared the diagnostic value of myocardial perfusion imaging (MPI) between the rest-stress ^{99 m}Tc-tetrofosmin protocol (Tc/Tc protocol) and simultaneous acquisition rest ^{99 m}Tc-tetrofosmin/stress ²⁰¹Tl dual-isotope protocol (SDI protocol) with a semiconductor camera.Methods and Results: We retrospectively studied 147 patients who underwent stress MPI using a cadmium-zinc-telluride camera and invasive coronary angiography within a 3-month interval. The Tc/Tc and SDI protocols were used in 59 and 88 patients, respectively. The sensitivity, specificity, and accuracy of the summed difference score in per-patient analysis were 56%, 85%, and 69%, respectively, for the Tc/Tc protocol and 89%, 82%, and 85%, respectively, for the SDI protocol. The area under the receiver operating characteristic curve was significantly better for the SDI than Tc/Tc protocol for the left anterior descending artery (0.836 vs. 0.674; P=0.0380), the left circumflex artery (0.754 vs. 0.599; P=0.0441), and in per-patient analysis (0.875 vs. 0.707; P=0.0135). There was no significant difference in the diagnostic accuracy of the summed stress score for any vessel or in per-patient analysis between the 2 protocols. CONCLUSIONS: The SDI protocol had a higher diagnostic accuracy for the detection of coronary ischemia than the Tc/Tc protocol.

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