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  • Title: Quinolone derivatives and their activities against methicillin-resistant Staphylococcus aureus (MRSA).
    Author: Gao C, Fan YL, Zhao F, Ren QC, Wu X, Chang L, Gao F.
    Journal: Eur J Med Chem; 2018 Sep 05; 157():1081-1095. PubMed ID: 30179746.
    Abstract:
    Methicillin-resistant Staphylococcus aureus (MRSA) is the most common pathogen both in hospital and community settings, and is capable of causing serious and even fatal infections. Several antibiotics have been approved for the treatment of infections caused by MRSA, but MRSA has already developed resistance to them. More than ever, it's imperative to develop novel, high effective and fast acting anti-MRSA agents. Quinolones are one of the most common antibiotics in clinical practice used to treat various bacterial infections, and some of them displayed excellent in vitro and in vivo anti-MRSA activities, so quinolone derivatives are one of the most promising candidates. This review summarizes the recent developments of quinolone derivatives with potential activity against MRSA, and the structure-activity relationship is also discussed.
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