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  • Title: Stress induces an increased hexose uptake in cultured cells.
    Author: Warren AP, James MH, Menzies DE, Widnell CC, Whitaker-Dowling PA, Pasternak CA.
    Journal: J Cell Physiol; 1986 Sep; 128(3):383-8. PubMed ID: 3018000.
    Abstract:
    Temperature-sensitive mutants have revealed a region of the herpes simplex virus 1 genome that affects both the uptake of hexose and the synthesis of heat shock proteins. Other inducers of heat-shock proteins, namely heat shock itself and arsenite, likewise induce an increased uptake of hexose. The increased uptake, like that induced by insulin, is insensitive to the presence of actinomycin D or cycloheximide. It is concluded that an increased hexose uptake, reflecting an activation or relocation of existing hexose transport protein, is a general biochemical response of stressed cells.
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