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  • Title: Circulating thymulin and thymosin-alpha 1 activity in pediatric acquired immune deficiency syndrome: in vivo and in vitro studies.
    Author: Rubinstein A, Novick BE, Sicklick MJ, Bernstein LJ, Incefy GS, Naylor PH, Goldstein AL.
    Journal: J Pediatr; 1986 Sep; 109(3):422-7. PubMed ID: 3018210.
    Abstract:
    Twenty-five children with acquired immune deficiency syndrome (AIDS) or AIDS-related complex had a characteristic pattern of T cell deficiency. Abnormally low plasma thymulin levels preceded the development of peripheral blood T cell abnormalities. In contrast to patients with congenital T cell deficiencies, our patients had elevated serum levels of thymosin-alpha 1. Treatment with thymosin fraction 5 in three children with AIDS resulted in only transient clinical and immunologic improvement.
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