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  • Title: MicroRNA-130a inhibits spermatogenesis by directly targeting androgen receptor in mouse Sertoli cells.
    Author: Li C, Yang B, Pan P, Ma Q, Wu Y, Zhang Z, Guo X, Ye J, Gui Y.
    Journal: Mol Reprod Dev; 2018 Oct; 85(10):768-777. PubMed ID: 30191667.
    Abstract:
    MicroRNAs (miRNAs) have been shown to play a key role in spermatogenesis. However, whether the miRNAs influence androgen/androgen receptor (AR) signaling during spermatogenesis remains unclear. Using a bioinformatic approach, a potential miRNA, miR-130a, which could bind to Ar-3'untranslated region directly was identified. The expression pattern of miR-130a was further characterized by quantitative real-time polymerase chain reaction. It was found that miR-130a was abundant in testis and its expression level was negatively correlated with age. Overexpression of miR-130a could inhibit AR expression both in vitro and in vivo. Moreover, the mice with an intratesticular injection of miR-130a showed defects in spermatogenesis and increased germ cell apoptosis. Taken together, these results suggest that miR-130a could negatively regulate AR expression in mouse Sertoli cell, which further cause defects in spermatogenesis.
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