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  • Title: The Radiological Differentiation of Hypervascular Intrahepatic Cholangiocarcinoma from Hepatocellular Carcinoma with a Focus on the CT Value on Multi-phase Enhanced CT.
    Author: Sano S, Yamamoto Y, Sugiura T, Okamura Y, Ito T, Ashida R, Ohgi K, Aramaki T, Nakanuma Y, Uesaka K.
    Journal: Anticancer Res; 2018 Sep; 38(9):5505-5512. PubMed ID: 30194209.
    Abstract:
    BACKGROUND/AIM: This study aimed to investigate whether hypervascular intrahepatic cholangiocarcinoma (HICC) can be differentiated from hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Among 100 patients with intrahepatic cholangiocarcinoma, 22 patients were diagnosed with HICC based on the computed tomography (CT) value in the late arterial phase as follows: the CT value of the tumor ≥ that of the liver parenchyma. The CT values of the HICC were compared to those of HCC cases (n=120). RESULTS: The CT value of HICC was lower in the unenhanced phase (UP) (p=0.016) and higher in the equilibrium phase (EP) (p<0.001) in comparison to HCC. The non-tumorous liver (odds ratio [OR]: 6.35, p=0.002) and an E/U ratio (the mean CT value of the tumor in the EP to that in the UP) of >2.3 (OR=13.1, p<0.001) were independent diagnostic factors for differentiating HICC from HCC. CONCLUSION: E/U ratio is useful for differentiating between HICC and HCC.
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