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  • Title: Detection of a polyoma virus-induced tumor-associated membrane antigen in mouse cells by the macrophage migration inhibition test.
    Author: Ramqvist T, Dalianis T, Reinholdsson G, Klein G, Szigeti R.
    Journal: Cancer Res; 1986 Oct; 46(10):5045-8. PubMed ID: 3019520.
    Abstract:
    Soluble membrane fractions derived from polyoma tumor cells trigger lymphocytes, derived from polyoma-immunized animals, but not from nonimmunized controls, to release the lymphokine, macrophage migration-inhibitory factor. The reaction can be blocked by sera from polyoma-bearing animals. Absorption of these sera with polyoma cells, but not with nonpolyoma cell lines, abrogates this activity. These findings suggest that there is a polyoma virus-induced membrane component that can induce polyoma-specific macrophage migration inhibition.
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