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  • Title: Vascular alpha-adrenoceptor blockade by E. coli endotoxin in the rat.
    Author: Auclair MC, Svinareff P, Schmitt H.
    Journal: Eur J Pharmacol; 1986 Aug 07; 127(1-2):121-4. PubMed ID: 3019722.
    Abstract:
    It has been previously shown that Escherichia coli endotoxin (ENDO) reduces the pressor effect of phenylephrine. This work attempted to define precisely the involvement of vascular alpha-adrenoceptors in this action. The dose-response curves of three alpha-agonists noradrenaline, St 587 and B-HT 933 in pithed rats were shifted rightwards by pretreatment (i.v. injection of 10 and 100 micrograms/kg) with ENDO. ENDO 10 and 30 micrograms shifted the dose-response curve of noradrenaline in perfused rat kidney. It can be suggested that ENDO has a potent blocking action on vascular alpha-adrenoceptors without evident discrimination between alpha 1 and alpha 2 subtypes.
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