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  • Title: (+)-3-PPP antagonizes the discriminative stimulus effects of (+)-N-allylnormetazocine.
    Author: Balster RL.
    Journal: Eur J Pharmacol; 1986 Aug 15; 127(3):283-6. PubMed ID: 3019734.
    Abstract:
    The functional significance of the reported affinity of (+)-3-PPP and (+)-N-allylnormetazocine (NANM) for the same binding site in rat brain membranes was assessed by studying (+)-3-PPP as a agonist and antagonist of (+)-NANM in rats trained to discriminate 5.0 mg/kg (+)-NANM from saline. Over a wide dose range, (+)-3-PPP was able to block the discriminative stimulus effects of (+)-NANM, with complete antagonism at 1.0 mg/kg i.p. Since (+)-NANM is a prototype sigma-opioid agonist, (+)-3-PPP is a good candidate for being a competitive sigma antagonist.
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