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  • Title: [Sodium Aescinate Induced Apoptosis of BGC-823 and AGS Cells by Inhibiting JAK-1/STAT-1 Signaling Pathway].
    Journal: Zhong Yao Cai; 2016 Sep; 39(9):2086-90. PubMed ID: 30209928.
    Abstract:
    OBJECTIVE: To investigate the mechanism of sodium aescinate on the apoptosis of gastric cancer BGC-823 cells and AGS cells. METHODS: CCK-8 assay was used to detect the cell viability of cancer cells; cells morphological changes were observed by inverted microscope; changes in nuclear morphology were observed by fluorescence inverted microscope after DAPI staining; cells apoptosis rate was detected by flow cytometry; Western blotting was used to detected the phosphorylation of JAK-1 and STAT-1; laser confocal microscopy was used to observed the nuclear translocation of STAT-1. RESULTS: Sodium aescinate inhibited cells proliferation in a concentration dependent manner, and changed the cells morphology and nuclear morphology, significantly up-regulated the apoptosis rate of gastric cancer BGC-823 cells and AGS cells, and down-regulated the phosphorylation of JAK-1, STAT-1 protein, inhibited the nuclear translocation of STAT-1. CONCLUSION: Sodium aescinate inhibit the proliferation and induce apoptosis in the gastric cancer BGC-823 cells and AGS cells, and this process can be implemented by inhibiting the JAK-1/STAT-1 signaling pathway.
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