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  • Title: Detection and characterization of DNA-anti-DNA complexes in a patient with systemic lupus erythematosus.
    Author: Bruneau CD, Edmonds JP, Hughes GR, Aarden L.
    Journal: Clin Exp Immunol; 1977 Jun; 28(3):433-6. PubMed ID: 302166.
    Abstract:
    DNase digestion of SLE serum, with consequent release of bound DNA antibody has been proposed as a method for the direct demonstration of circulating DNA-anti-DNA complexes. In the present studies on the serum of a girl with active SLE nephritis, circulating DNA-anti-DNA complexes were demonstrated at the precise time of relapse of SLE nephritis. Ultracentrifugation showed that these complexes were of low molecular weight.
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