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  • Title: Polyomavirus small T antigen enhances replication of viral genomes in 3T6 mouse fibroblasts.
    Author: Berger H, Wintersberger E.
    Journal: J Virol; 1986 Nov; 60(2):768-70. PubMed ID: 3022009.
    Abstract:
    Transfection of 3T6 cells with a cloned polyomavirus genome encoding only large T antigen resulted in DNA replication with only about 1/10 the efficiency of wild-type viral DNA coding for all three T antigens. This replication defect was at least in part overcome by the simultaneous transfections of polyomavirus genomes which allowed the expression of small T antigen. We conclude that polyomavirus small T antigen has a (probably indirect) role in replication.
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