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  • Title: Oncogenes and a specific chromosomal abnormality associated with small-cell lung cancers.
    Author: Taya Y.
    Journal: Jpn J Clin Oncol; 1986 Sep; 16(3):199-202. PubMed ID: 3022029.
    Abstract:
    Studies on oncogenes and a specific chromosomal abnormality involved in small-cell lung cancers are reviewed. Amplification and/or expression of one of the three myc family oncogenes (c-myc, N-myc, L-myc) were found in 21 of 31 small-cell lung cancers. However, oncogenes were not detected in DNAs of small-cell lung cancers by the NIH3T3 transfection assay. In addition, a specific deletion on the short arm of chromosome number 3 was often associated with small-cell lung cancers. These characteristics are quite different from those of non-small-cell lung cancers.
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