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  • Title: Peptide hormone production in small cell lung carcinomas with particular reference to gastrin-releasing peptide.
    Author: Yamaguchi K, Abe K, Adachi I, Otsubo K, Nagasaki K, Suzuki M, Maruno K, Asanuma F, Tsuchihashi T, Miyake Y.
    Journal: Jpn J Clin Oncol; 1986 Sep; 16(3):235-41. PubMed ID: 3022032.
    Abstract:
    Tissues of 50 small cell lung carcinomas were examined for production of 17 peptide hormones. Only when the concentration of a peptide detected in the tumor was 10 pmol or more per g wet weight, was the peptide considered to be produced by the tumor. The frequency of production of at least one of these peptide hormones was 84%, and that of two or more hormones was 50%. These results indicate that peptide hormone production is a very common phenomenon in small cell lung carcinoma. Of the peptide hormones examined, gastrin-releasing peptide is produced with the highest frequency, suggesting that this peptide could play an important role in small cell lung carcinoma.
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