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  • Title: Xylopsides A-D, four rare guaiane dimers with two unique bridged pentacyclic skeletons from Xylopia vielana.
    Author: Xie YG, Guo YG, Wu GJ, Zhu SL, Cheng TF, Zhang Y, Yan SK, Jin HZ, Zhang WD.
    Journal: Org Biomol Chem; 2018 Sep 26; 16(37):8408-8412. PubMed ID: 30221279.
    Abstract:
    Four unprecedented guaiane dimers, xylopsides A-D (1-4), were isolated and identified from the roots of Xylopia vielana. The structures of 1-4 were elucidated by spectroscopic analysis, Cu Kα X-ray crystallography and CD spectra. 1-4 showed two bridged pentacyclic skeletons between two guaiane-type sesquiterpenes, which were characterized as two different bridged ring systems. Among these compounds, 4 exhibited a moderate inhibitory activity against the production of nitric oxide with an IC50 value of 25.7 μM in RAW264.7 cells stimulated by LPS.
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