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  • Title: Lack of effect of chronic imipramine administration on beta-adrenoceptor density on rat lymphocytes.
    Author: Chalecka-Franaszek E, Vetulani J.
    Journal: Pol J Pharmacol Pharm; 1986; 38(4):385-90. PubMed ID: 3022259.
    Abstract:
    Chronic administration of imipramine with drinking water to Wistar rats for two months did not affect the [3H]dihydroalprenolol binding to lymphocytic membranes, though the treatment depressed the radioligand binding to cerebral cortical membranes. The result suggests that the beta-adrenoceptor downregulation caused by the antidepressant in the central nervous system is not reflected in the lymphocytes.
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