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  • Title: Chronic lead exposure alters dopaminergic mechanisms in rat pituitary.
    Author: Lucchi L, Govoni S, Memo M, Missale C, Spano PF, Trabucchi M.
    Journal: Toxicol Lett; 1986 Sep; 32(3):255-60. PubMed ID: 3022429.
    Abstract:
    The effect of chronic lead treatment on pituitary dopamine (DA) D2 receptors was studied by measuring (-)sulpiride-displaceable [3H]spiroperidol-binding and DA-inhibited adenylate cyclase. Receptor number was reduced in lead-exposed animals and bromocriptine was less able to inhibit cyclase activity in pituitary homogenates. In addition, the capacity of DA to inhibit the VIP-stimulated cAMP formation was decreased.
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