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  • Title: [Stimulation of mitochondrial oxidative enzymes in acute cooling and its catecholamine mechanisms].
    Author: Kulinskiĭ VI, Medvedev AI, Kuntsevich AK.
    Journal: Vopr Med Khim; 1986; 32(5):84-8. PubMed ID: 3022485.
    Abstract:
    Acute cooling of rats led to stimulation of NAD+-dependent isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH) and NAD(P)+-transhydrogenase (TH) but did not affect the NADP+-ICDH activity in liver, heart and skeletal muscle mitochondria. After pretreatment of the animals with propranolol the stimulating effect was decreased, thus suggesting that endogenous catecholamines and beta-adrenoreceptors are of importance in activation of NAD+-ICDH, SDH and TH. The effects of cooling, noradrenaline and cAMP did not summarize. Role of catecholamines in stimulation of mitochondrial oxidative enzymes under conditions of cooling is discussed.
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