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  • Title: Cytoplasmic inclusions and virus-like particles in blast cells in acute lymphoblastic leukemia.
    Author: Ishihara T, Matsumoto N, Yamashita Y, Takahashi M, Uchino F, Inoue M, Yano S, Tanaka H, Shinohara K, Kaneko T.
    Journal: Acta Pathol Jpn; 1986 Aug; 36(8):1231-9. PubMed ID: 3022545.
    Abstract:
    Cytoplasmic inclusions and virus-like particles are described in blast cells of peripheral blood from a 16-year-old female with acute lymphoblastic leukemia. Three kinds of inclusions were identified on electron microscopy. The first type of inclusion was single membrane-bounded vacuoles, some of which contained virus-like particles, the second was lysosome-like structures, and the third appeared to be of mitochondrial origin. Virus-like particles were round in shape and had a diameter of 26 to 58 nm. They consisted of an electron-dense outer membrane and an electron-lucent core. At the present time the exact nature and significance of these virus-like particles still remain unclear.
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