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  • Title: Dimericursones A and B: two unprecedented hexacyclic dimeric diterpenoids from the root barks of Jatropha curcas.
    Author: Liu JQ, Xu Y, Xiao Q, Huang JD, Ma JJ, Lian CL, Huang MY, Du ZB, Wang CF.
    Journal: Org Biomol Chem; 2018 Sep 26; 16(37):8305-8310. PubMed ID: 30225495.
    Abstract:
    Dimericursones A and B (1 and 2), two unprecedented hexacyclic dimeric diterpenoids, were obtained from the root barks of Jatropha curcas. Their structures were elucidated by extensive spectroscopic analysis, electronic circular dichroism calculations, and single-crystal X-ray diffraction. Dimericursone B (2) showed significant inhibition on nitric oxide production of lipopolysaccharide-induced RAW264.7 macrophages with IC50 values of 5.65 μM.
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