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  • Title: The corticotropin-releasing hormone stimulation test in chronic schizophrenia.
    Author: Roy A, Pickar D, Doran A, Wolkowitz O, Gallucci W, Chrousos G, Gold P.
    Journal: Am J Psychiatry; 1986 Nov; 143(11):1393-7. PubMed ID: 3022612.
    Abstract:
    During a drug-free period a group of schizophrenic subjects (N = 9) showed normal mean basal plasma ACTH and cortisol levels in association with normal plasma ACTH and cortisol responses to an infusion of corticotropin-releasing hormone (CRH). Administration of fluphenazine had no effect on basal ACTH and cortisol levels or their responses to CRH (N = 8). These data differ from those previously reported in depressed patients, who showed elevated basal cortisol values in association with a blunted ACTH response to CRH, and add to a growing body of literature which suggests that hypothalamic-pituitary-adrenal regulation is less disturbed in schizophrenia than in depression.
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