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  • Title: Characterization of rabbit genes for synovial cell collagenase.
    Author: Fini ME, Gross RH, Brinckerhoff CE.
    Journal: Arthritis Rheum; 1986 Nov; 29(11):1301-15. PubMed ID: 3022758.
    Abstract:
    To provide tools for understanding collagenase gene expression in rheumatoid arthritis, we have isolated and characterized genomic clones for rabbit synovial cell collagenase. These clones represent 2 types of collagenase gene, at least 1 of which is transcribed in synovial fibroblasts. By examining the rabbit genome in situ, we provide evidence that there are only 2 different synovial cell collagenase genes found in a haploid genome. Amplification of these genes is not a mechanism for collagenase messenger RNA induction by phorbol esters.
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