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  • Title: Degradative enzyme systems in cartilage.
    Author: Ehrlich MG, Armstrong AL, Treadwell BV, Mankin HJ.
    Journal: Clin Orthop Relat Res; 1986 Dec; (213):62-8. PubMed ID: 3022974.
    Abstract:
    There appears to be a final common pathway in the pathogenesis of osteoarthritis, regardless of the initiating cause. This involves an increase in degradative enzymes that arise from the cartilage. Both proteoglycan- and collagen-degrading enzymes, active at a neutral pH, increase in proportion to the severity of the arthritis until a final end-stage state is reached. This increase in enzyme activity may be triggered by release of a synovial messenger protein similar to interleukin-1. It is suggested by studies in an animal model that inhibition of these enzymes could lead to treatment of osteoarthritis.
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