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  • Title: Age related changes of glucagon binding and activity in isolated rat hepatocytes.
    Author: Poli G, Cassader M, Chiarpotto E, Biasi F, Cecchini G, Pagano G.
    Journal: Int J Tissue React; 1986; 8(5):367-71. PubMed ID: 3023252.
    Abstract:
    Hepatocytes isolated from young and old rats were compared for glucagon binding and its biological effect. Liver cells from young rats showed a receptor binding of the hormone significantly higher than cells from old rats. Such a behaviour was paralleled by the activity of the hormone. In fact, the glucagon-dependent stimulation of adenylate cyclase in the hepatocytes from the former group of animals was twice as high as in the latter.
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