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  • Title: Exosomal miR-1246 in body fluids is a potential biomarker for gastrointestinal cancer.
    Author: Wei C, Li Y, Huang K, Li G, He M.
    Journal: Biomark Med; 2018 Oct; 12(10):1185-1196. PubMed ID: 30235938.
    Abstract:
    AIM: The aim was to systematically evaluate whether exosomal miRNAs could be regarded as potential minimally invasive biomarkers of diagnosis for gastrointestinal cancer. METHODS: A systematic review and meta analysis of exosomal miRNA expression in gastrointestinal cancer were performed. RESULTS: A total of 370 articles were retrieved from PubMed and EMBASE. The summary receiver operating characteristic curves of three miRNAs (miR-21, miR-1246 and miR-4644) were drawn, miR-21, miR-1246 and miR-4644 exhibited sensitivities of 0.66, 0.920 and 0.750, respectively; specificities were 0.87, 0.958 and 0.769, respectively; and areas under the curve for discriminating gastrointestinal cancer patients from control subjects were 0.876, 0.969 and 0.827, respectively. CONCLUSION: Exosome miR-1246 had the highest level of diagnostic efficiency, which indicated that miR-1246 could be a biomarker.
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