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  • Title: Intranuclear vacuoles in Creutzfeldt-Jakob disease.
    Author: Cervos-Navarro J, Cruz-Sanchez F, Gimeno-Alava A, Ferszt R.
    Journal: Neuropathol Appl Neurobiol; 1986; 12(5):477-82. PubMed ID: 3024051.
    Abstract:
    In an electron microscopic study of brain biopsy material from a case with Creutzfeldt-Jakob disease intranuclear vacuoles containing membrano-vesicular structures were found. To our knowledge this finding has not been previously reported in human spongiform encephalopathies. It may represent a specific alteration associated with Creutzfeldt-Jakob disease, and suggests the possibility of nuclear infection.
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