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  • Title: [Phase II study of bronchial artery infusion of mitomycin C in non-small cell lung cancer].
    Author: Nakamura Y, Shimizu E, Hohjo F, Hashimoto Y, Mutsuura S, Yamasaki K, Mukai J, Tada T, Sone S, Yamashita T.
    Journal: Gan To Kagaku Ryoho; 1986 Dec; 13(12):3436-9. PubMed ID: 3024579.
    Abstract:
    A phase II study of bronchial artery infusion of mitomycin C (MMC) was performed in 14 patients with non-small cell lung cancer (6 patients with adenocarcinoma, 6 patients with squamous cell carcinoma and 2 patients with large cell carcinoma). MMC at a dose of 20 mg was infused into the bronchial artery (total dose 20-60 mg, mean 27 mg). Among the 14 patients, one with adenocarcinoma of the lung showed partial response. The response rate for bronchial artery infusion of MMC was thus 7.1%. The toxic effects included anemia (35.7%), leukopenia (28.6%), thrombopenia (14.3%), elevation of GPT (14.3%), anorexia (14.3%), nausea (7.1%) and eruption (7.1%).
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