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  • Title: Clinical value of 99mTc-HYNIC-TOC SPECT/CT for the diagnosis primary small cell neuroendocrine carcinomas of the nasal cavity and paranasal sinuses.
    Author: Chen H, Li Y, Gao X, Shen X.
    Journal: Clin Imaging; 2018; 52():365-369. PubMed ID: 30248495.
    Abstract:
    PURPOSE: To evaluate the diagnostic value of 99mTc-HYNIC-TOC SPECT/CT in the detection of primary small cell neuroendocrine carcinomas of the nasal cavity and paranasal sinuses. METHODS: From September 2005 to November 2015, 19 patients (mean age 53.9 years, range 37-77; male 6, female 13) with sinonasal small cell neuroendocrine carcinoma (SNEC) underwent whole-body 99mTc-HYNIC-TOC SPECT/CT scan. RESULTS: All 19 primary lesions were detected by 99mTc-HYNIC-TOC SPECT/CT. A total of 212 metastatic lesions were identified by organ-based analysis, and the sensitivity and specificity of 99mTc-HYNIC-TOC SPECT/CT were 90.5% and 92.3%, respectively. The application of 99mTc-HYNIC-TOC SPECT/CT resulted in the detection of a higher number of lesions in 11 patients (57.9%) and in the successful alteration of the treatment in 7 patients (36.8%) compared with the morphological imaging methods. CONCLUSION: 99mTc-HYNIC-TOC scintigraphy is an effective method for the detection of the sinonasal SNEC.
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