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  • Title: Pressor sensitivity to angiotensin I and angiotensin II during the development of experimental renal hypertension in the rat.
    Author: Doyle AE, Harrap SB, Torresi J.
    Journal: Clin Exp Pharmacol Physiol; 1986 Jul; 13(7):563-8. PubMed ID: 3024889.
    Abstract:
    Treatment with the potent angiotensin converting enzyme inhibitor perindopril completely prevented any rise in blood pressure in the 2-kidney, 1-clip (2K1C) model of renal hypertension in rats. Withdrawal of this inhibitor was followed by a slow rise in blood pressure. In 2K1C rats treated with perindopril, pressor responses to angiotensin I fell during the treatment period, but returned to normal after the inhibitor was stopped. Pressor responses to angiotensin II (AII) increased during treatment with perindopril; this was presumably due to increased receptor sensitivity consequent on the falls in endogenous AII levels. Responses to AII fell to control levels after the inhibitor was stopped. It is concluded that an increased pressor sensitivity to AII is not the cause of the slowly developing hypertension in the 2K1C model of hypertension, and that the slow pressor response to AII must be due to other factors.
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