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  • Title: Effect of mitochondrial cytochromes and haem content on cytochrome P450 in Saccharomyces cerevisiae.
    Author: Meussdoerffer F, Fiechter A.
    Journal: J Gen Microbiol; 1986 Aug; 132(8):2187-93. PubMed ID: 3025336.
    Abstract:
    It is well established that the mitochondrial and the microsomal cytochromes in Saccharomyces cerevisiae are regulated differently. Mutations affecting the mitochondrial cytochromes aa3 or c had no effect on the concentration of the microsomal cytochrome P450 even during haem limitation. Moreover, a defect in the cytochrome P450 gene did not affect mitochondrial cytochromes. However, a regulatory mutation present in strain SG1 decreased both mitochondrial and microsomal cytochrome contents. This mutation also affected the intracellular haem concentration. The haem precursor 5-aminolaevulinate increased both mitochondrial and microsomal cytochrome contents. Our results indicate that carbon source and haem concentration are involved in the regulation of cytochrome P450.
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