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  • Title: Site of gossypol inhibition of steroidogenesis in purified mouse Leydig cells.
    Author: Pearce S, Sufi SB, O'Shaughnessy PJ, Donaldson A, Jeffcoate SL.
    Journal: J Steroid Biochem; 1986 Nov; 25(5A):683-7. PubMed ID: 3025516.
    Abstract:
    Gossypol, a phenolic compound that has been studied as a potential male contraceptive, inhibits basal and LH-stimulated testosterone release from Leydig cells in vitro. The present study investigates the mechanism of this inhibition using preparations of purified mouse Leydig cells. Gossypol inhibited LH-stimulated progesterone, 17-hydroxyprogesterone and androstenedione production by mouse Leydig cells incubated in vitro. It also inhibited dibutyryl cyclic AMP-stimulated production of testosterone but was without effect in the presence of added pregnenolone or 25-hydroxycholesterol. These results suggest gossypol exerts its major inhibitory effect on Leydig cell function at a point between LH-dependent stimulation of cyclic AMP dependent protein kinase activity and increased availability of cholesterol for side chain cleavage.
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