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  • Title: Antineutrophil cytoplasmic antibodies negative levamisole-induced leukocytoclastic vasculitis: a presumed case and literature review.
    Author: Kunzler D, Lagrimas L, Vo T, DeCrescenzo A, Kaltwasser K, Wilson J.
    Journal: Int J Dermatol; 2018 Dec; 57(12):1411-1416. PubMed ID: 30255497.
    Abstract:
    Levamisole-contaminated cocaine toxicity is a serious emerging public health concern, and providers should be aware of its presentation and management. Most cases of levamisole-induced vasculitis/vasculopathy (LIV) are associated with high antineutrophil cytoplasmic antibodies (ANCA). We describe a unique case of a cocaine user who presented with an acute purpuric eruption and negative ANCA laboratory findings. A brief clinical overview of LIV, spanning from patient presentation to treatment, is provided. In addition, we present a summary of all cases of ANCA-negative vasculitis identified via a PubMed literature review.
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