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  • Title: Low-dose grape pomace and omija fruit extract is more effective than high-dose in lowering oxidative stress and fat-pad mass in db/db mice.
    Author: Cho SJ, Kim HJ, Choi JY, Kwon EY, Kim YJ, Ryu R, Choi MS, Park YB.
    Journal: Food Sci Biotechnol; 2017; 26(6):1709-1714. PubMed ID: 30263709.
    Abstract:
    Previous studies have shown that the mixture of extracts of grape pomace and omija (GO) improved oxidative stress and obesity in mice. This study first investigated the dose-response effects of GO on oxidative stress and fat-pad mass. Male C57BL/KsJ-db/db mice were fed the following three experimental diets for 7 weeks: a normal control, high-dose grape pomace plus omija (HGO; 0.5% grape pomace plus 0.05% omija fruit, w/w), and low-dose grape pomace plus omija (LGO; 0.3% grape pomace plus 0.05% omija fruit, w/w). The LGO significantly decreased white adipose tissues weights, as well as ameliorated the plasma lipid profiles. The antioxidant effects of LGO led to a significant decrease in the erythrocytic H2O2 and thiobarbituric acid-reactive substance levels, while LGO increased erythrocytic antioxidant activities. These results suggest that LGO is more effective than HGO in lowering oxidative stress and body fat mass in db/db mice.
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