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  • Title: GTP regulation of platelet-activating factor binding to human neutrophil membranes.
    Author: Ng DS, Wong K.
    Journal: Biochem Biophys Res Commun; 1986 Nov 26; 141(1):353-9. PubMed ID: 3026378.
    Abstract:
    Radiolabeled ligand binding studies showed that specific receptors for platelet-activating factor are present in human neutrophil membranes. GTP at 10(-7) to 10(-3) M decreased the specific binding of platelet-activating factor to neutrophil membranes in a dose-dependent manner. Inhibition of platelet-activating factor binding was also induced by other guanine nucleotides but not by adenine nucleotides. Our results suggest that platelet-activating factor receptor in human neutrophil membranes may be coupled to a guanine nucleotide binding protein.
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