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  • Title: Ubiquitination and adaptive responses to BRAF inhibitors in Melanoma.
    Author: Saei A, Eichhorn PJA.
    Journal: Mol Cell Oncol; 2018; 5(5):e1497862. PubMed ID: 30263945.
    Abstract:
    Response to targeted therapies is limited by the activation or inhibition of feedback loops. Here we report the ubiquitin specific peptidase 28/F-box WD repeat-containing protein 7 (USP28/FBW7) complex functions as a negative regulator of mitogen-activated protein kinase (MAPK) pathway by targeting v-raf murine sarcoma viral oncogene homolog B (BRAF) for degradation, a process which is lost in a large proportion of BRAF mutant melanoma patients, resulting in resistance to BRAF inhibitor therapies.
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