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Title: A comparison of conventional and dynamic radiotherapy planning techniques for early-stage breast cancer utilizing deep inspiration breath-hold. Author: Vikström J, Hjelstuen MH, Wasbø E, Mjaaland I, Dybvik KI. Journal: Acta Oncol; 2018 Oct; 57(10):1325-1330. PubMed ID: 30264635. Abstract: BACKGROUND: For breast cancer patients, radiotherapy increases the risk of cardiac disease. Conventional three-dimensional conformal radiotherapy (3D-CRT) in deep inspiration breath-hold (DIBH) has demonstrated substantial reduction in cardiac doses as compared to treatment in free breathing. The purpose of this treatment planning study is to investigate if dynamic techniques in combination with DIBH could improve the quality of the treatment plans and further reduce the doses to the heart and other organs at risk for early-stage breast cancer patients. MATERIAL AND METHODS: CT series in DIBH of 16 patients from a previous study were used. For each patient, treatment plans were generated with the following three techniques: 3D-CRT, tangential intensity-modulated radiotherapy (tIMRT) and volumetric modulated arc therapy with partial arcs (pVMAT). The treatment planning was performed focusing on planning target volume (PTV) coverage, V95% >95%. Dose-volume histograms were calculated and compared. Doses to the heart, left anterior descending (LAD) coronary artery, ipsilateral and contralateral lung as well as the contralateral breast (CB) were assessed. RESULTS: All plans fulfilled the criterion on PTV coverage. Compared to 3D-CRT, the dynamic plans obtained better dose homogeneity and conformity. The mean heart dose was similar for 3D-CRT and tIMRT, 1.3 and 1.1 Gy, respectively, but significantly higher for pVMAT, 1.6 Gy. The median V25 Gy to the heart was 0% for all techniques. The LAD doses were generally lower with the dynamic techniques. The mean doses to the ipsi- and contralateral lung and CB were similar with tIMRT and 3D-CRT but significantly higher with pVMAT. V20 Gy to the ipsilateral lung was significantly lower with tIMRT compared to 3D-CRT. CONCLUSION: tIMRT and 3D-CRT with DIBH are better techniques for sparing heart tissue and other organs at risk without compromising target coverage in early-stage breast cancer irradiation compared to VMAT.[Abstract] [Full Text] [Related] [New Search]