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  • Title: Alkaline protease deficiency in the cr-1 (crisp) mutant of Neurospora crassa.
    Author: Savtchenko ES, Terenzi HF, Jorge JA.
    Journal: Braz J Med Biol Res; 1986; 19(1):27-32. PubMed ID: 3026533.
    Abstract:
    The adenyl cyclase deficient cr-1 mutant of Neurospora crassa grew poorly in bovine serum albumin as an alternative and only source of either sulfur, nitrogen or carbon. The low growth of the cr-1 mutant in protein was correlated with limited secretion of extracellular alkaline protease. The defect was specific for the cr-1 mutant and was suppressed by exogenous cyclic AMP. Cyclic AMP relieved protease deficiency under carbon, nitrogen or sulfur limiting conditions to unequal extents. Protease stimulation was greatest under carbon-limited conditions, but the resulting growth was least. Most of the cyclic AMP-mediated increase of alkaline protease was extracellular.
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