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  • Title: Molecular Modeling for Better Understanding of Cucumovirus Pathology.
    Author: Salánki K, Gellért Á, Nemes K, Divéki Z, Balázs E.
    Journal: Adv Virus Res; 2018; 102():59-88. PubMed ID: 30266176.
    Abstract:
    Cucumber mosaic virus (CMV) is a small RNA virus capable of infecting a wide variety of plant species. The high economic losses due to the CMV infection made this virus a relevant subject of scientific studies, which were further facilitated by the small size of the viral genome. Hence, CMV also became a model organism to investigate the molecular mechanism of pathogenesis. All viral functions are dependent on intra- and intermolecular interactions between nucleic acids and proteins of the virus and the host. This review summarizes the recent data on molecular determinants of such interactions. A particular emphasis is given to the results obtained by utilizing molecular-based planning and modeling techniques.
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