These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen.
    Author: Bikel I, Montano X, Agha ME, Brown M, McCormack M, Boltax J, Livingston DM.
    Journal: Cell; 1987 Jan 30; 48(2):321-30. PubMed ID: 3026642.
    Abstract:
    A murine recombinant Neo(r) retrovirus encoding the SV40 small t antigen was used to infect Balb/c 3T3 CIA31 cells. From analyses of G418-resistant clones containing at least as much intact t as Cos-1 cells, we found that t, alone, had no detectable A31 transforming activity. In contrast, we noted that SV40 large T promoted A31 agar colony formation when present over a 5- to 7.5-fold concentration range. However, at the low end of the spectrum, its transforming effect was manifest inefficiently except in the presence of t. Thus a major role for t in the SV40 transforming mechanism is to enhance directly or indirectly the transforming function of T.
    [Abstract] [Full Text] [Related] [New Search]